Industrial perspectives for personalized microneedles

• Remmi Danae Baker-Sediako,
• Benjamin Richter,
• Matthias Blaicher,
• Michael Thiel and
• Martin Hermatschweiler

Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70

• that can overcome these challenges [27]. Specifically, light-based 3D printing techniques such as stereolithography (SLA), digital light processing (DLP), and two-photon polymerization (2PP) simplify the rapid prototyping workflow when compared to traditional micro- and nanofabrication methods [28][29

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• biotherapeutics, drugs, and vaccines through the skin. A wide range of microneedle structure, design, geometry, and microneedle array densities is manufactured using different rapid prototyping and microfabrication technologies such as deep reactive ion etching (DRIE) [2], lithography [3], hot embossing [4], and

• methods developed for microneedles, these rapid prototyping methods do not require expensive cleanroom facilities, and complex geometries can be realised in a shorter time and with less technical expertise. This is a major advantage for fabrication of microneedle patch arrays requiring integration of

• incompatible with rapid prototyping and lack the flexibility that other manufacturing methods such as 3D printing provide. These attractive alternative methods of manufacturing microneedles from polymers, instead of silicon, are considered below. Fabrication and use of polymer microneedles Polymer materials

High-throughput synthesis of modified Fresnel zone plate arrays via ion beam lithography

• Kahraman Keskinbora,
• Umut Tunca Sanli,
• Margarita Baluktsian,
• Corinne Grévent,
• Markus Weigand and
• Gisela Schütz

Beilstein J. Nanotechnol. 2018, 9, 2049–2056, doi:10.3762/bjnano.9.194

• writing/milling capability. IBL allows for rapid prototyping of high-resolution FZPs that can be used for high-resolution imaging at soft X-ray energies. Here, we discuss improvements in the process enabling us to write zones down to 15 nm in width, achieving an effective outermost zone width of 30 nm

• is direct-write ion beam lithography (IBL) and machining [32][33][34]. A well-known advantage of IBL is the ease of rapid prototyping of small-scale microfluidic, optical or electronic nanodevices. IBL has recently been applied for fabricating high-resolution functional FZPs [28][35][36] and for the

Surface functionalization of 3D-printed plastics via initiated chemical vapor deposition

• Christine Cheng and
• Malancha Gupta

Beilstein J. Nanotechnol. 2017, 8, 1629–1636, doi:10.3762/bjnano.8.162

• flexibility and rapid prototyping. The ability to functionalize the surfaces of 3D-printed objects allows the bulk properties, such as material strength or printability, to be chosen separately from surface properties, which is critical to expanding the breadth of 3D printing applications. In this work, we

3D Nanoprinting via laser-assisted electron beam induced deposition: growth kinetics, enhanced purity, and electrical resistivity

• Brett B. Lewis,
• Robert Winkler,
• Xiahan Sang,
• Pushpa R. Pudasaini,
• Michael G. Stanford,
• Harald Plank,
• Raymond R. Unocic,
• Jason D. Fowlkes and
• Philip D. Rack

Beilstein J. Nanotechnol. 2017, 8, 801–812, doi:10.3762/bjnano.8.83

• : additive manufacturing; beam induced processing; 3D printing; direct-write; electron beam induced deposition; microscopy; nanofabrication; pulsed laser; purification; rapid prototyping; Introduction The first fully incorporated 3D transistor logic was reported in 2012 [1]. Further 3D device concepts and

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

• Alexandra M. Greiner,
• Adria Sales,
• Hao Chen,
• Sarah A. Biela,
• Dieter Kaufmann and
• Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

• computers, such as methods using the self-organization of macromolecular systems. Computer-assisted methods, also known as solid free-form or rapid prototyping, initally require the design of a computer model with a special software. The second step is then the realization of the computer model with a

Fabrication of hybrid nanocomposite scaffolds by incorporating ligand-free hydroxyapatite nanoparticles into biodegradable polymer scaffolds and release studies

• Balazs Farkas,
• Marina Rodio,
• Ilaria Romano,
• Alberto Diaspro,
• Romuald Intartaglia and
• Szabolcs Beke

Beilstein J. Nanotechnol. 2015, 6, 2217–2223, doi:10.3762/bjnano.6.227

• modulus of our rapid prototyping-fabricated scaffolds can be adjusted over a range of four orders of magnitude without any implied modifications concerning the chemical composition of the resin itself. In this study, we present the combination of two laser methods (PLA and MPExSL) to incorporate HA NPs

• dissolved in purified PPF and in the PPF:DEF (7:3 w/w) blend. Diethyl fumarate (DEF) is applied as diluent to reduce the resin viscosity as needed for the proper resin recast for MPExSL. MPExSL Mask-projected excimer laser stereolithography (MPExSL) is a rapid prototyping stereolithography method, relying

Low-cost formation of bulk and localized polymer-derived carbon nanodomains from polydimethylsiloxane

• Juan Carlos Castro Alcántara,
• Mariana Cerda Zorrilla,
• Lucia Cabriales,
• Luis Manuel León Rossano and
• Mathieu Hautefeuille

Beilstein J. Nanotechnol. 2015, 6, 744–748, doi:10.3762/bjnano.6.76

• inside the microscopic volume of etched material [7]. In this particular case, the PDC organization was highly dependent on lasing conditions and the process proved to be useful to produce localized fluorescent nanodomains in a PDMS matrix with a direct, controlled, rapid-prototyping method, similar to

Electron-beam induced deposition and autocatalytic decomposition of Co(CO)₃NO

• Florian Vollnhals,
• Martin Drost,
• Fan Tu,
• Esther Carrasco,
• Andreas Späth,
• Rainer H. Fink,
• Hans-Peter Steinrück and
• Hubertus Marbach

Beilstein J. Nanotechnol. 2014, 5, 1175–1185, doi:10.3762/bjnano.5.129

• sizes [13], the possibility of 3D fabrication, e.g., pillars, and rapid prototyping capabilities [14]. A related FEBIP approach is electron-beam induced surface activation (EBISA) [7]. In EBISA, a suitable substrate, e.g., SiOx [7][15][16][17][18], TiO2 [19], or a thin porphyrin film on Ag(111) [8], is

Biocalcite, a multifunctional inorganic polymer: Building block for calcareous sponge spicules and bioseed for the synthesis of calcium phosphate-based bone

• Xiaohong Wang,
• Heinz C. Schröder and
• Werner E. G. Müller

Beilstein J. Nanotechnol. 2014, 5, 610–621, doi:10.3762/bjnano.5.72

• suitable matrix to embed bone forming cells for rapid prototyping bioprinting/3D cell printing applications. Keywords: biocalcite; bioprinting; bone; bone formation; calcareous spicules; sponge; Introduction The size and complexity of a metazoan taxon is correlated with the dimensioning of its respective

• vascularization and tissue supply with oxygen. Much progress has been achieved in rapid prototyping/3D printing techiques in the last years. 3D printing is a computer-controlled layer-by-layer technology. Thereby a binder (binding solution) is printed into each layer of powder, a step-wise process that finally

• RAW 264.7 cells show a reduced capacity to express the gene for tartrate-resistant acid phosphatase. For rapid prototyping bioprinting we are using a computer-aided tissue engineering printer (3D-Bioplotter; Corporate EnvisionTEC GmbH, Gladbeck; Germany). With this technology we succeeded to embed